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The birth and life of lipid droplets: learning from the hepatitis C virus.: Lipid droplets in HCV infection

By Philippe Roingeard and Marion Depla

Abstract

International audienceLDs (lipid droplets) are probably the least well-characterized cellular organelles. Having long been considered simple lipid storage depots, they are now considered to be dynamic organelles involved in many biological processes. However, most of the mechanisms driving LDs biogenesis, growth and intracellular movement remain largely unknown. As for other cellular mechanisms deciphered through the study of viral models, HCV (hepatitis C virus) is an original and relevant model for investigations of the birth and life of these organelles. Recent studies in this model have raised the hypothesis that the HCV core protein induces the redistribution of LDs through the regression and regeneration of these organelles in specific intracellular domains

Topics: Lipid droplet, organelle dynamics, hepatitis C virus, MESH: Animals, MESH: Hepacivirus, MESH: Humans, MESH: Lipid Metabolism, MESH: Lipids, MESH: Organelles, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Publisher: 'Portland Press Ltd.'
Year: 2011
DOI identifier: 10.1042/BC20100119
OAI identifier: oai:HAL:inserm-00664942v1

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