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Antimycobacterial activity of new N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives

By Daniele Zampieri, Maria Grazia Mamolo, Luciano Vio, Maurizio Romano, Nataša Skoko, Marco Baralle, Valentina Pau and Alessandro De Logu


N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains

Topics: Pyridine-2-carboxamidrazone derivatives, Mycobacteria other than tuberculosis (MOTT), Antimycobacterial activity
Year: 2016
DOI identifier: 10.1016/j.bmcl.2016.05.053
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