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Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer

By Arianna Bellazzo, Giulio Di Minin and Licio Collavin


Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFa signaling

Topics: DAB2IP, AIP1, tumor necrosis factor, cancer cell invasivity
Year: 2015
DOI identifier: 10.1080/23723556.2014.1002719
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