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The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation.

By P Giraudi, V Becerra, V Marin, N Chavez-Tapia, C Tiribelli and N Rosso


Non-alcoholic fatty liver disease is characterized by an initial accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key role in liver fibrogenesis by an increased activation and an altered profile of genes involved in the turnover of extracellular matrix components. To reproduce in-vitro the functional cell connections observed in vivo it is essential to consider cell-to-cell proximity and interaction. The aim of this study was to determine the response to free fatty acids in a simultaneous co-culture model of hepatocytes and hepatic stellate cells

Topics: Extracellular matrix turnover, Fibrogenesis, Hepatic stellate cells, Hepatocytes, Steatosis
Year: 2015
DOI identifier: 10.1016/j.yexmp.2014.12.006
OAI identifier: oai:arts.units.it:11368/2843805
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