TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.

Abstract

We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients

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Archivio istituzionale della ricerca - UniversitĂ  di Trieste

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Last time updated on 12/11/2016

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