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Association of calcium concentration with pulse pressure in older women: Data from a large population-based multicentric study

By L. Mateus-Hamdan, O. Beauchet, Y. Rolland, A.M. Schott and C. Annweiler


Objective High arterial pulse pressure is a predictor of cardiovascular morbimortality. Mineral metabolism has been associated with blood pressure regulation. Our objective was to determine which variable among serum calcium, parathyroid hormone and 25-hydroxyvitamin D concentrations, was associated with pulse pressure among older adults. Design Cross-sectional study corresponding to the baseline assessment of the EPIDOS study. Setting Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse. Participants Randomized sample of 610 community-dwelling older women (mean age 80.2±3.5 years) using no antihypertensive drugs. Measurements Serum calcium, parathyroid hormone and 25-hydroxyvitamin D concentrations; supine pulse pressure after 15 minutes of rest (hypertension defined as pulse pressure >50mmHg). Age, body mass index, the number of morbidities and of drugs daily taken, diabetes mellitus, dysthyroidy, the use of estrogenic drugs, smoking, alcohol consumption, practice of a regular physical activity, creatinine clearance, and the effects of season and study centers were used as potential confounders. Results Hypertensive participants (n=539) had higher calcium concentrations than normotensive ones (94.33±4.12mg/L versus 93.28±3.36mg/L respectively, P=0.040). There were no between-group differences for serum parathyroid hormone and 25-hydroxyvitamin D concentrations. The multiple logistic regressions examining the serum calcium, parathyroid hormone and 25-hydroxy vitamin D concentrations as predictors of hypertension found an association only with calcium (adjusted odds ratio=1.19, P=0.015), but not with parathyroid hormone (adjusted OR=1.01, P=0.349) or 25-hydroxyvitamin D concentration (adjusted OR=0.99, P=0.971). Conclusion Increased serum calcium concentration was independently and positively associated with high pulse pressure in our study, possibly due to increased arterial stiffness. Interventions aimed at normalizing calcaemia may be attractive to prevent hypertension and cardiovascular risk in older adults

Topics: Calcium, older adults, parathyroid hormone, Pulse pressure, Vitamin D
Publisher: 'Springer Science and Business Media LLC'
Year: 2013
DOI identifier: 10.1007/s12603-013-0412-1
OAI identifier:
Provided by: Okina

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