Regular walking exercise attenuates lower-limb\ud cutaneous microvascular endothelial dysfunction in postsurgical\ud varicose-vein patients. This study assessed the\ud effects of upper-limb exercise training on lower-limb cutaneous\ud microvascular function in this patient group. Six\ud post-surgical (4–5 weeks) varicose-vein patients completed\ud an 8-week arm-crank exercise training programme.\ud Changes in cutaneous microvascular function of the lower\ud leg were assessed using laser Doppler Xowmetry\ud and iontophoretic administration of endothelial-dependent\ud and -independent agonists [acetylcholine (ACh) and sodium\ud nitroprusside (SNP), respectively]. At 8 weeks, median\ud lower-limb cutaneous vasodilator responsives to ACh and\ud SNP remained unchanged relative to baseline (e.g. 6 mC:\ud 37 (interquartile range 24–63) vs. 40 (20–71) PU and 35\ud (23–48) vs. 38 (21–64) PU, respectively for the supine\ud position). Upper-limb exercise appears ineffective for\ud improving lower-limb cutaneous microvascular function in\ud post-surgical varicose-vein patients. Therefore, limb speci-\ud ficity appears an important factor in optimal exercise\ud prescription for these patients
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