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Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones

By Paul A. Clarke, Soraia Santos and William H. C. Martin

Abstract

The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route. This is demonstrated by the synthesis of highly substituted tetrahydropyran-4-ones and is quantified by a series of recognised metrics, which demonstrate the efficiency of combining PASE over conventional synthetic strategies

Year: 2007
DOI identifier: 10.1039/b700923b
OAI identifier: oai:eprints.whiterose.ac.uk:3376

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