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Suppression of the postoperative neutrophil leucocytosis following neoadjuvant chemoradiotherapy for rectal cancer and implications for surgical morbidity

By Stuart Kerr, Markos Klonizakis and Robert Glynne-Jones

Abstract

Objective: The extent to which neoadjuvant chemoradio-\ud therapy for rectal cancer influences postoperative morbid-\ud ity is controversial. This study investigated whether this\ud treatment suppresses the normal perioperative inflamma-\ud tory response and explored the clinical implications.\ud Method: Prospective databases were queried to identify\ud 37 consecutive study patients undergoing definitive\ud surgery following 5-FU ⁄ capecitabine-based chemoradio-\ud therapy and 35 consecutive untreated control patients\ud operated upon for rectal or rectosigmoid cancer. Preop-\ud erative (< 10 days) and postoperative (< 24 h) neutrophil\ud counts, along with morbidity data, were confirmed\ud retrospectively. Univariate and multivariate analyses\ud assessed the apparent effect of chemoradiotherapy on\ud change in neutrophil count. The latter’s association with\ud postoperative morbidity was then examined.\ud Results: Sufficient data were available for 34 study and\ud 27 control patients. Repeated-measures ANCOVA\ud revealed significant differences between their periopera-\ud tive neutrophil counts (P = 0.02). Of the other charac-\ud teristics which differed between the groups, only age\ud and tumour location were prognostically significant\ud regarding perioperative change in neutrophil count.\ud Accounting for relevant covariates, chemoradiotherapy\ud was significantly associated with a suppressed perioper-\ud ative neutrophil leucocytosis. Local postoperative com-\ud plications affected 25 of 61 patients, who had lower\ud perioperative neutrophil increases than their counter-\ud parts (P = 0.016).\ud Conclusion: Chemoradiotherapy appears to suppress the\ud perioperative inflammatory response, thereby increasing\ud susceptibility to local postoperative complications

Topics: A300 Clinical Medicine
Publisher: Wiley-Blackwell
Year: 2010
DOI identifier: 10.1111/j.1463-1318.2009.01858.x
OAI identifier: oai:eprints.lincoln.ac.uk:3559

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