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Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation

By Paul A. Clarke, Andrey V. Zaytzev and Adrian C. Whitwood

Abstract

The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved

Year: 2007
DOI identifier: 10.1016/j.tetlet.2007.05.141
OAI identifier: oai:eprints.whiterose.ac.uk:3384

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