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Analysis of Somatic Alterations in Cancer Genome: From SNP Arrays to Next Generation Sequencing
Abstract
International audienceIn this chapter we consider basic hypothesis, problem statements and technological and computa- tional solutions for analysis of copy number alterations in tumor genomes. We provide a data mining tech- nique (based on the GAP method described in (Popova et al., 2009)) which allows extraction of absolute copy numbers and allelic contents from the whole genome copy number variation and allelic imbalance profiles obtained by SNP arrays or NGSSimilar works
This paper was published in HAL Descartes.
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