Skip to main content
Article thumbnail
Location of Repository

Reversing microcrystalline tests: an analytical approach to recycling of microcrystals from drugs of abuse

By Leonie Elie, Mark Baron, Ruth Croxton and Mathieu Elie


A combined analysis of microcrystalline tests followed by LC-MS or GC-MS analysis is described. Microcrystalline tests are shown to be non-destructive as addition products formed were easily dissociated after the application of an appropriate solvent. Subsequent analysis of the sample was done to quantify the recovery of the drug. Examples were performed using the date rape drug γ-hydroxybutyrate (GHB) and the synthetic opioid methadone

Topics: F151 Pharmaceutical Chemistry, F100 Chemistry, F180 Analytical Chemistry
Publisher: Elsevier
Year: 2011
DOI identifier: 10.1016/j.forsciint.2011.01.008
OAI identifier:

Suggested articles


  1. (1982). Analysis of methadone and metabolites in biological fluids with gas chromatography-mass spectrometry, doi
  2. (2006). Chemical composition and structure of the microcrystals formed between silver(I) and γ-hydroxybutyric acid and γ-hydroxyvaleric acid, doi
  3. (2007). Comparative analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate using GC/MS and HPLC, doi
  4. (1997). Drug proficiency test false positives: a lack of critical thought, doi
  5. (2008). Enhancement of microcrystalline identification of γ-hydroxybutyrate, doi
  6. (1969). Isolation and Identification of Drugs, doi
  7. (2009). Microcrystalline tests in forensic drug analysis, in: R.A. Meyers (Ed.), Encyclopaedia of Analytical Chemistry, doi
  8. (1969). Modern Microcrystal Tests for Drugs, first ed.,
  9. (2004). Simultaneous analysis of gamma-hydroxybutyric acid and its precursors in urine using liquid chromatography-tandem mass spectrometry, doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.