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Development and characterization of a bio-hybrid skin-like stretchable electrode

By E. Buselli, Alan M. Smith, Liam M. Grover, A. Levi, R. Allman, V. Mattoli, A. Menciassi and L. Beccai

Abstract

This work presents the design, fabrication and characterization of a polymer based stretchable electrode for cell monitoring. The final goal is the development of innovative bio-hybrid skin-like tactile sensors with mammalian cells as core biological elements; to achieve such aim the enabling technological approach is pursued in this investigation. Electrodes are needed to detect cells response, thus the first step of the bio-hybrid system fabrication is the development of a platform able to record such response and transmit it to the external world. The stretchable electrode is composed by a conductive layer (few Ǻ of Ti plus 90 nm of Au) on a polymeric substrate (1 mm thick PDMS membrane). Cellular adhesion was verified and cellular response to an induced electrode strain of 1% was detected through fluorescence microscopy. Fluorescence intensities were 104.82 ± 9.64 a.u. and 129.66 ± 13.06 a.u. prior and during electrode strain, respectively. Electromechanical characterization of the stretchable electrode revealed excellent stability and reliability within the 1% strain, which is the operative range identified for the future tactile sensor application. Results showed that the electrode was conductive up to 14% of strain. Furthermore, frequency impedance measurements demonstrated the electrode capability of detecting presence of cells

Topics: Q1, RL, RS, TA, TK
Publisher: Elsevier
Year: 2011
OAI identifier: oai:eprints.hud.ac.uk:9920
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