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Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine

By E.I. Nep and Barbara R Conway

Abstract

Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain\ud cimetidine as novel drug. The formulations were compared with similar formulations using\ud hydroxypropyl methylcelluose (Methocel®), gum arabic, carboxy methylcellulose (Blanose®), or\ud ethyl cellulose (Ethocel®) as polymer matrix. Also binary composite matrices containing grewia\ud gum and the reference polymers (40 %w/w total polymer concentration in a ratio of 1:1) were\ud directly compressed. In addition to tablet properties, swelling, erosion, kinetics of drug release from\ud the matrices and stability of the tablet formulations were also investigated. In vitro drug release\ud studies reveal that grewia gum can control the release of cimetidine from tablets for up to 12 hours.\ud This strong sustained-release potential of grewia polysaccharide gum was superior to hydrophilic\ud matrices of hydroxypropyl methylcellulose, carboxy methylcellulose and gum arabic. The release\ud of drug from the grewia polysaccharide gum matrices follows Higuchi kinetic models. There was\ud synergy between grewia gum and HPMC in delaying the release of cimetidine from tablets. Grewia\ud gum may therefore prove a useful excipient when used alone, or in combination with other\ud polymers to modify the release of soluble drugs from polymeric matrice

Topics: Q1, QD
Publisher: Pharmainfo Publications
Year: 2010
OAI identifier: oai:eprints.hud.ac.uk:10143

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Citations

  1. A three-layer guar gum matrix tablet for oral controlled delivery of Formulation Release exponent (n) Korsmeye r-Peppas (r2) Zeroorder kinetic (r2) Firstorder kinetic (r2) Higuchi model (r2) Similarity factor (f2)
  2. A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. doi
  3. (1985). Analysis of Fickian and nonFickian drug release from polymers. Pharm Acta Helv.
  4. (2010). Characterization of grewia gum, a potential pharmaceutical excipient. doi
  5. Compressed xanthan and karaya gum matrices: erosion and drug release mechanisms. doi
  6. Compression, mechanical and release properties of paracetamol tablet containing acid treated grewia gum.
  7. (2005). Design and evaluation of 1- and 3-layer matrices of verapamil hydrochloride for sustaining its release. doi
  8. (2008). Effect of grewia gum on the mechanical properties of paracetamol tablet formulations.
  9. (2006). Formulation and in vitro-in vivo evaluation of extended- release matrix tablet of zidovudine: influence of combination of hydrophilic and hydrophobic matrix formers. doi
  10. (2000). Formulation variables affecting drug release from xanthan gum matrices at laboratory scale and pilot scale. AAPS PharmSciTech. doi
  11. (1985). Handling of Bulk Solids.
  12. (2008). In vitro evaluations of konjac glucomannan and xanthan gum mixtures as sustained release material of matrix tablet. Carbohydrate Polymers doi
  13. (1996). Mathematical comparison of curves with an emphasis on dissolution profiles.
  14. (1983). Mechanism of solute release from porous hydrophilic polymers. doi
  15. (1963). Mechanism of sustained-action medication: theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. doi
  16. (2004). Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride. doi
  17. (2007). Pharmaceutical preformulation. In:
  18. (2009). Physicochemical and mechanical characterization of galactomannan from Mimosa scabrella: effect of drying method. Carbohydrate Polymers doi
  19. (1998). Relationship between swelling, erosion and drug release from hydrophilic natural gum mini-matrix formulations. doi
  20. Release of furosemide from multiple unit and single unit preparations containing different viscosity grades of sodium alginate. doi
  21. (2003). Release of pentoxifylline from xanthan gum Matrix Tablets. Drug Development and Industrial Pharmacy doi
  22. Some physicochemical properties of grewia gum. doi
  23. (1997). Sustained release of acetaminophen from heterogeneous matrix tablets, influence of polymer ratio, polymer loading and coactive on drug release. Pharm Dev Technol. doi
  24. (2000). Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Research focus, doi
  25. Swelling and drug release behaviour of xanthan gum matrix tablets. doi
  26. Swelling, erosion and release behaviour of alginate-based matrix tablets. doi
  27. (1966). The flow properties of granular doi
  28. The Rheological Properties of Grewia Gum. doi
  29. (2002). Three-layer gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. doi
  30. (2006). Use of hydrophilic natural gums in the formulation of sustained-release matrix tablets of tramadol hydrochloride, AAPS PharmSciTech. doi
  31. (1993). Zero-order release from hydrocolloid matrices.

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