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HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy

By M. Boothby, A.M. Umpleby, F. Shojaee-Moradie, J. W. Tomlinson, L. L. Gathercole, K. C. (Kirsty Claire) McGee, S. Das and Mohsen Shahmanesh

Abstract

Purpose of the study\ud Fractional clearance rate of apolipoprotein B100-containing\ud lipoproteins is reduced in HIV infection before and\ud after antiretroviral (ARV) treatment [1]. We compared\ud lipoprotein lipase (LPL) activity and gene expression in\ud HIV-positive subjects before and 6 months after ARV with\ud HIV-negative controls.\ud Methods\ud Fasting blood post heparin total and hepatic lipase activity,adiponectin, leptin, insulin, glucose, and lipid measurementswere made in 32 HIV-infected and 15 HIVnegative\ud controls. LPL was estimated by subtractinghepatic lipase from total lipase. Adiponectin, LPL andhormone sensitive lipase (HSL) gene expression weremeasured from iliac crest subcutaneous fat biopsies.Patients were tested before, and 6 months after randomisation to AZT/3TC (n = 15) or TDF/FTC (n = 17) with EFV.Between-group comparison was by Mann-Whitney andpaired samples by the Wilcoxon signed rank tests.\ud Summary of results\ud There were no differences in gender, ethnicity, baseline\ud BMI, regional fat distribution (whole body DEXA) and\ud visceral (VAT) and subcutaneous fat (SAT) measured by\ud abdominal CT scans between controls and patients. Trunk\ud fat/BMI ratio, VAT and VAT:SAT ratio significantly\ud increased after 6-month ARV therapy (p = 0.01). There\ud were no differences between groups in serum NEFA,HOMA and leptin levels. Selected other results are shown\ud in Table 1.\ud Conclusion\ud Post heparin lipoprotein lipase activity is reduced in HIV\ud and does not return to control levels after 6 months of\ud ARV therapy. AZT-containing regimens are associated\ud with a greater increase in LPL, LPL gene expression and\ud plasma adiponectin than TDF

Topics: R1
Publisher: BioMed Central
Year: 2008
OAI identifier: oai:wrap.warwick.ac.uk:518

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Citations

  1. (2005). Antiretroviral treatment reduces verylow-density lipoprotein and intermediate-density lipoprotein apolipoprotein B fractional catabolic rate in human immunodeficiency virus-infected patients with mild dyslipidemia. doi

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