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Serum leptin and its relation to anthropometric measures of\ud obesity in pre-diabetic Saudis

By Nasser M. Al-Daghri, Omar S. Al-Attas, Khalid Al-Rubeaan, Mehad Mohieldin, Mohammad Al-Katari, Alan F. Jones and Sudhesh Kumar


Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in prediabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis.\ud Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using\ud standard laboratory procedures.\ud Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2–72] vs 3.9 [0.8–20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8–44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25–34.8] ng/mL) (p = 0.046). After adjustment for BMI and\ud gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects.\ud Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the\ud non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity

Topics: R1
Publisher: BioMed Central Ltd.
Year: 2007
OAI identifier:

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  1. (1997). [No authors listed]: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes care doi
  2. (1996). al-Daghari N: Prevalence of hypercholesterolemia in Saudi Arabia, epidemiological study. doi
  3. (2004). Al-Mobeireek A: Diabetes mellitus in Saudi Arabia. Saudi Med J doi
  4. (1994). Armstrong K: Blood lipid concentrations and other cardiovascular risk factors among Saudis. Fam Pract doi
  5. (2003). Asia Pacific Cohort Studies Collaboration: The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care doi
  6. Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):S5-S10. doi
  7. (2001). Cardiovascular Health Study: Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders: the Cardiovascular Health Study. Diabetes Care doi
  8. (1990). Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA doi
  9. (1996). Carotid artery intima – media thickness in elderly patients with NIDDM and in nondiabetic subjects. Stroke doi
  10. (1997). Despres JP: Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia doi
  11. (1997). Diabetes, asymptomatic hyperglycemia, and 22-year mortality in black and white men. The Chicago Heart Association Detection Project in Industry Study. Diabetes Care doi
  12. (1993). Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care doi
  13. (1979). DL: Diabetes and cardiovascular disease: The Framingham Study. JAMA doi
  14. Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes.
  15. (2001). F: Relationship of leptin level with metabolic disorders and hypertension in Japanese type 2 diabetes mellitus patients. doi
  16. (2004). Fernandez ML: Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women.
  17. (1991). Ferrannini E: Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes doi
  18. (2002). Gender differences in factors influencing insulin resistance in elderly hyperlipemic non-diabetic subjects. Cardiovasc Diabetol
  19. (1997). Hanefeld M: Relation of free and specifically bound leptin to insulin secretion in patients with impaired glucose tolerance (IGT). Exp Clin Endocrinol Diabetes doi
  20. (1998). Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Stroke doi
  21. (2001). Impaired fasting glucose concentrations in nondiabetic patients with ischemic heart disease: a marker for a worse prognosis. Am Heart J doi
  22. (2001). Impaired glucose tolerance as a disease. doi
  23. (1996). Khoja T: High prevalence of overweight and obesity in Saudi Arabia. Int J Obes Relat Metab Disord doi
  24. (1994). Laws A: Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease. Diabetologia doi
  25. (2001). Leptin levels in the obese African parturient. doi
  26. (2005). Liao EY: Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta doi
  27. (1985). Lipids, diabetes, and coronary heart disease: insights from the Framingham Study. Am Heart J doi
  28. (2003). Longitudinal Study of Aging: The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal study of aging. Diabetes doi
  29. (1975). Major factors in the development of diabetes mellitus in 10,000 men. Arch Intern Med doi
  30. (1971). MI: Mortality in adults with and without diabetes in a national cohort of the US population, doi
  31. (1996). MP: Leptin concentrations in relation to overall adiposity and regional body fat distribution in Mexican Americans. Int J Obes Relat Metab Disord
  32. (2003). nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord doi
  33. (1995). Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med doi
  34. (2000). Overview of chronic diseases in the Kingdom of Saudi Arabia. Saudi Med J
  35. (2000). Pattern of smoking among parents of schoolboys.
  36. (1997). Prevalence of glucose intolerance in urban and rural communities in Saudi Arabia. Diabet Med doi
  37. (1985). RC: Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia doi
  38. (1992). RD: A comparison of the relationships of the glucose tolerance test and the glycated haemoglobin assay with diabetic vascular disease in the community. The Islington Diabetes Survey. Diabetes Res Clin Pract doi
  39. (2004). SE: Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. doi
  40. (1996). Serum immunoreactive-leptin concentrations in normalweight and obese humans. doi
  41. (2003). Serum leptin is elevated in Saudi Arabian patients with metabolic syndrome and coronary artery disease. Diabet Med doi
  42. (1987). Tarui S: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism doi
  43. (2000). Teutsch SM: Diabetes mellitus, impaired fasting glucose, atherosclerotic risk factors, and prevalence of coronary heart disease. doi
  44. (2002). The leptin, a new hormone of adipose tissue: clinical findings and perspectives in geriatrics. Arch Gerontol Geriatr doi
  45. (1999). The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. doi
  46. (1992). Tibblin G: Hyperinsulinaemia is not a major coronary risk factor in elderly men: The study of men born in 1913. Diabetologia doi
  47. (2002). When did leptin become a reproductive hormone? Semin Reprod Med doi
  48. (1994). Why is insulin not a risk factor for coronary heart disease? Diabetologia doi

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