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The amphioxus genome and the evolution of the chordate karyotype

By Nicholas H. Putnam, Thomas Butts, David E. K. Ferrier, Rebecca F. Furlong, Uffe Hellsten, Takeshi Kawashima, Marc Robinson-Rechavi, Eiichi Shoguchi, Astrid Terry, Jr-Kai Yu, Èlia Benito-Gutiérrez, Inna Dubchak, Jordi Garcia-Fernàdez, Jeremy J. Gibson-Brown, Igor V. Grigoriev, Amy C. Horton, Pieter J. de Jong, Jerzy Jurka, Vladimir V. Kapitonov, Yuji Kohara, Yoko Kuroki, Erika Lindquist, Susan Lucas, Kazutoyo Osoegawa, Len A. Pennacchio, Asaf A. Salamov, Yutaka Satou, Tatjana Sauka-Spengler, Jeremy Schumtz, Tadasu Shin-I, Atsushi Toyoda, Asao Fujiyama, Linda Z. Holland, Peter W. H. Holland, Nori Satoh, Daniel S. Rokhsar and Marianne Bronner-Fraser

Abstract

Lancelets ('amphioxus') are the modern survivors of an ancient chordate lineage, with a fossil record dating back to the Cambrian period. Here we describe the structure and gene content of the highly polymorphic approx520-megabase genome of the Florida lancelet Branchiostoma floridae, and analyse it in the context of chordate evolution. Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization, as well as a description of two genome-wide duplications and subsequent reorganizations in the vertebrate lineage. These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution

Topics: Caltech Library Services
Publisher: Nature Publishing Group
Year: 2008
OAI identifier: oai:authors.library.caltech.edu:11220
Provided by: Caltech Authors

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