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The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection \ud

By L. J. White, M. Waris, Patricia Cane, D. James Nokes and Graham Medley


Human respiratory syncytial virus (hRSV) transmission dynamics are inherently cyclical, and the observed genetic diversity (between groups A and B) also appears to have a repeating pattern. A key unknown is the extent to which genetic variants interact immunologically, and thus impact on epidemiology. We developed a novel mathematical model for hRSV transmission including seasonal forcing of incidence and temporary intra- and inter-group partial immunity. Simultaneous model fits to data from two locations (England & Wales, UK, and Turku, Finland) successfully reproduced the contrasting infection dynamics and group A/B dominance patterns. Parameter estimates are consistent with direct estimates. Differences in the magnitude and seasonal variation in contact rate between the two populations alone could account for the variation in dynamics between these populations. The A/B group dominance patterns are explained by reductions in susceptibility to and infectiousness of secondary homologous and heterologous infections. The consequences of the observed dynamic complexity are discussed

Topics: RA
Publisher: Cambridge University Press
Year: 2005
OAI identifier: oai:wrap.warwick.ac.uk:740

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  4. (2002). Correlation between respiratory syncytial virus genotype and severity of illness. doi
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  10. (2001). Hospitalization rates for respiratory syncytial virus infection in premature infants born during two consecutive seasons. Pediatr Infect Dis J doi
  11. (1991). Infectious diseases of humans dynamics and control.
  12. (1982). Measles in England and Wales I: An analysis of factors underlying seasonal patterns. doi
  13. (2001). Modelling epidemics caused by respiratory syncytial virus (RSV). doi
  14. (2001). Molecular epidemiology of respiratory syncytial virus. Rev Med Virol doi
  15. (1992). Numerical recipes in C: the art of scientific 288 L J. White and otherscomputing, 2nd edn. Cambridge:
  16. of the art of new vaccines (www.who.init/ vaccine_research/documents/new_vaccines/en/). World Health Oganisation Initiative for Vaccine Research,
  17. (2002). On the determinants of population structure in antigenically diverse viral pathogens. doi
  18. (1991). Pattern of respiratory syncytial virus epidemics in Finland: two-year cycles with alternating prevalence of groups A and B. doi
  19. (2002). Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique. doi
  20. (1997). Repiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. doi
  21. (2003). Respiratory syncytial virus epidemiology in a birth cohort from Kilifi District, Kenya: infection in the first year of life. doi
  22. (2000). Respiratory syncytial virus genetic and antigenic diversity. Clin Microbiol Rev doi
  23. (2000). Respiratory syncytial virus in adults. Clin Microbiol Rev doi
  24. (2001). Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis doi
  25. (1976). Respiratory syncytial virus infections within families. doi
  26. (2003). Respiratory syncytial virus: concerns and control. Pediatr Rev doi
  27. (1961). Respiratory syncytial virus. 1. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children.
  28. (1979). Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. doi
  29. (1999). Risk factors for severe respiratory syncytial virus infection leading to hospital admission in children in the Western Region of The Gambia. doi
  30. (1986). Risk of primary infection and reinfection with respiratory syncytial virus. doi
  31. (2001). Seasonally forced dynamics explored as switching between attractors. Physica D doi
  32. (1997). The dynamics of cocirculating influenza strains conferring partial crossimmunity. doi
  33. (1988). The fusion glycoproteins of human respiratiry syncytial virus of subgroups A and B: sequence conservation provides a structural basis for antigenic relatedness. doi
  34. (1985). Two distinct subtypes of human respiratory syncytial virus. doi
  35. (2002). UN Indicators on Population (http:/www.un.org/Depts/ unsd/social/population.htm). United Nations Statistics Division,
  36. (2004). Unifying the epidemiological and evolutionary dynamics of pathogens. Science doi

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