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Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones

By El-Nasir Lalani and Burchell B


Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones

Topics: Gunn-rat liver; Uridine diphosphate; Glucuronyltransferase; Alkyl ketones, Cells, Digestive System, Hepatology
Publisher: eCommons@AKU
Year: 1979
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Provided by: eCommons@AKU

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