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The contribution of age structure to cell population responses to targeted therapeutics

By Pierre Gabriel, Shawn P. Garbett, Vito Quaranta, Darren R. Tyson and Glenn F. Webb


International audienceCells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the agents used to synchronize the cells potentially have other unknown effects on the cells. An alternative approach is to determine the age structure in the population and account for the cell cycle positional effects post hoc. Here we provide a formalism to use quantifiable age distributions from live cell microscopy experiments to parameterize an age-structured model of cell population response

Topics: Cell cycle, intermitotic time, renewal equation, exponentially modified gaussian, [ MATH.MATH-AP ] Mathematics [math]/Analysis of PDEs [math.AP], [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Publisher: Elsevier
Year: 2012
DOI identifier: 10.1016/j.jtbi.2012.07.001
OAI identifier: oai:HAL:hal-00649178v2
Provided by: Hal-Diderot

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