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Development of an injectable composite for bone regeneration

By Sylvaine Jacquart, Agathe Belime, Christel Pigasse, Robin Siadous, Mohammed Fatnassi, Solène Tadier, Rachel Auzély-Velty, Sophie Girod-Fullana, Reine Bareille, Christine Roques, Nadia El Kissi, Fani Anagnostou, Aurélien Bignon, Delphine Cordier, Christian Rey, Fabien Brouillet, Joelle Amédée, Hélène Galliard and Christèle Combes

Abstract

International audienceWith the development of minimally invasive surgical techniques, there is a growing interest in the research and development of injectable biomaterials especially for orthopedic applications. In a view to enhance the overall surgery benefits for the patient, the BIOSINJECT project aims at preparing a new generation of mineral-organic composites for bone regeneration exhibiting bioactivity, therapeutic activity and easiness of use to broaden the application domains of the actual bone mineral cements and propose an alternative strategy with regard to their poor resorbability, injectability difficulties and risk of infection. First, a physical-chemical study demonstrated the feasibility of self-setting injectable composites associating calcium carbonate-calcium phosphate cement and polysaccharides (tailor-made or commercial polymer) in the presence or not of an antibacterial agent within the composite formulation. Then, bone cell response and antimicrobial activity of the composite have been evaluated in vitro. Finally, in order to evaluate resorption rate and bone tissue response an animal study has been performed and the histological analysis is still in progress. These multidisciplinary and complementary studies led to promising results in a view of the industrial development of such composite for dental and orthopaedic applications

Topics: Calcium carbonate-calcium phosphate, Cement, Composite, Bone regeneration, [ SPI.MAT ] Engineering Sciences [physics]/Materials, [ SPI.NANO ] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics
Publisher: Elsevier Masson
Year: 2013
DOI identifier: 10.1016/j.irbm.2013.01.008
OAI identifier: oai:HAL:hal-00869869v1
Provided by: Hal-Diderot

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