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Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors.

By S Abdelsayed, N T Ha Duong, J Hai, M Hémadi, J M El Hage Chahine, P Verbeke and N Serradji


International audienceChlamydia trachomatis (Ct) is a bacterial human pathogen responsible for the development of trachoma, the worldwide infection leading to blindness, and is also a major cause of sexually transmitted diseases. As iron is an essential metabolite for this bacterium, iron depletion presents a promising strategy to limit Ct proliferation. The aim of this study is to synthesize 3-isoxazolidone derivatives bearing known chelating moieties in an attempt to develop new bactericidal anti-Chlamydiaceae molecules. We have investigated the paths by which these new compounds affect Ct serovar L2 development in HeLa cells, in the presence or absence of exogenously added iron. The iron-chelating properties of these molecules were also determined. Our data reveal important bactericidal effects which are distinguishable from those due to iron chelation

Topics: MESH : 3-Isoxazolidone; Chlamydia trachomatis inhibitors; Iron, [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], [ SDV.SP.PHARMA ] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Publisher: Elsevier
Year: 2014
DOI identifier: 10.1016/j.bmcl.2014.06.056
OAI identifier: oai:HAL:hal-01130939v1
Provided by: Hal-Diderot
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