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Emergence of cytotoxic resistance in cancer cell populations : From individual-level mechanisms to population-level consequences

By Tommaso Lorenzi, Rebecca H. Chisholm, Alexander Lorz, Annette K Larsen, Luís Neves de Almeida, Alexandre Escargueil and Jean Clairambault


International audienceWe formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells

Topics: [ MATH.MATH-AP ] Mathematics [math]/Analysis of PDEs [math.AP]
Publisher: HAL CCSD
Year: 2015
DOI identifier: 10.1051/itmconf
OAI identifier: oai:HAL:hal-01249235v1
Provided by: Hal-Diderot

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