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Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division

By Shawn N. Jordan, Tim Davies, Yelena Zhuravlev, Julien Dumont, Mimi Shirasu-Hiza and Julie C. Canman

Abstract

International audienceCytokinesis, the physical division of one cell into two, is thought to be fundamentally similar in most animal cell divisions and driven by the constriction of a contractile ring positioned and controlled solely by the mitotic spindle. During asymmetric cell divisions, the core polarity machinery (partitioning defective [PAR] proteins) controls the unequal inheritance of key cell fate determinants. Here, we show that in asymmetrically dividing Caenorhabditis elegans embryos, the cortical PAR proteins (including the small guanosine triphosphatase CDC-42) have an active role in regulating recruitment of a critical component of the contractile ring, filamentous actin (F-actin). We found that the cortical PAR proteins are required for the retention of anillin and septin in the anterior pole, which are cytokinesis proteins that our genetic data suggest act as inhibitors of F-actin at the contractile ring. Collectively, our results suggest that the cortical PAR proteins coordinate the establishment of cell polarity with the physical process of cytokinesis during asymmetric cell division to ensure the fidelity of daughter cell formation

Topics: [ SDV.BC ] Life Sciences [q-bio]/Cellular Biology
Publisher: Rockefeller University Press
Year: 2016
DOI identifier: 10.1083/jcb.201510063
OAI identifier: oai:HAL:hal-01305455v1
Provided by: Hal-Diderot
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