Skip to main content
Article thumbnail
Location of Repository

Extracting non-linear integrate-and-fire models from experimental data using dynamic I–V curves

By Laurent Badel, Sandrine Lefort, Thomas K. Berger, Carl C. H. Petersen, Wulfram Gerstner and Magnus J. E. Richardson

Abstract

The dynamic I–V curve method was recently introduced for the efficient experimental generation of reduced neuron models. The method extracts the response properties of a neuron while it is subject to a naturalistic stimulus that mimics in vivo-like fluctuating synaptic drive. The resulting history-dependent, transmembrane current is then projected onto a one-dimensional current–voltage relation that provides the basis for a tractable non-linear integrate-and-fire model. An attractive feature of the method is that it can be used in spike-triggered mode to quantify the distinct patterns of post-spike refractoriness seen in different classes of cortical neuron. The method is first illustrated using a conductance-based model and is then applied experimentally to generate reduced models of cortical layer-5 pyramidal cells and interneurons, in injected-current and injected- conductance protocols. The resulting low-dimensional neuron models—of the refractory exponential integrate-and-fire type—provide highly accurate predictions for spike-times. The method therefore provides a useful tool for the construction of tractable models and rapid experimental classification of cortical neurons

Topics: RC0321, QA
Publisher: Springer
Year: 2008
OAI identifier: oai:wrap.warwick.ac.uk:2605

Suggested articles

Citations

  1. (2006). 117:500–544 HuysQJM,AhrensMB,PaninskiL
  2. (2005). B a d e lL ,L e f o r tS ,B r e t t eR ,P e t e r s e nC C H ,G e r s t n e rW ,R i c h a r d s o n MJE (2008) Dynamic I–V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces. doi
  3. (2002). Spiking neuron models. Cambridge University Press, London Burkitt AN (2006b) A review of the integrate-and-fire neuron model: II. Inhomogeneous synaptic input and network properties.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.