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The microenvironment matters: estrogen deficiency fuels cancer bone metastases

By Laura E. Wright and Theresa A. Guise


Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR

Topics: Bone Neoplasms, secondary, Breast Neoplasms, pathology, Estrogens, deficiency, Osteoporosis, Postmenopausal, Tumor Microenvironment
Publisher: American Association for Cancer Research
Year: 2014
DOI identifier: 10.1158/1078-0432.CCR-14-0576
OAI identifier:
Provided by: IUPUIScholarWorks

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