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Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

By B. Ghetti, A. L. Oblak, B. F. Boeve, K. A. Johnson, B. C. Dickerson and M. Goedert

Abstract

Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms

Topics: FTDP-17 MAPT, tau aggregation, neurofibrillary tangle, Pick body, tau, [F18]-T807
Publisher: Wiley
Year: 2015
DOI identifier: 10.1111/nan.12213
OAI identifier: oai:scholarworks.iupui.edu:1805/8956
Provided by: IUPUIScholarWorks

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