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Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution

By Constain Hugo Salamanca Mejía, Bruno Felipe Urbano and Andres Floreal Olea Carrasco

Abstract

This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer ∆µ°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer

Topics: Biología, Ecología, Biology, Ecology
Publisher: Departamento de Ciencias Biológicas
Year: 2011
DOI identifier: 10.1590/S1984-82502011000400009
OAI identifier: oai:repository.icesi.edu.co:10906/79900
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