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Roadmap on biosensing and photonics with advanced nano-optical methods

By Enzo Di Fabrizio, Sebastian Schlücker, Jérôme Wenger, Raju Regmi, Hervé Rigneault, Giuseppe Calafiore, Melanie West, Stefano Cabrini, Monika Fleischer, Niek F van Hulst, Maria F Garcia-Parajo, Annemarie Pucci, Dan Cojoc, Charlotte A E Hauser and Ming Ni

Abstract

This roadmap, through the contributions of ten groups worldwide, contains different techniques,\ud methods and materials devoted to sensing in nanomedicine. Optics is used in different ways in\ud the detection schemes. Raman, fluorescence and infrared spectroscopies, plasmonics, second\ud harmonic generation and optical tweezers are all used in applications from single molecule\ud detection (both in highly diluted and in highly concentrated solutions) to single cell\ud manipulation. In general, each optical scheme, through device miniaturization and\ud electromagnetic field localization, exploits an intrinsic optical enhancement mechanism in order\ud to increase the sensitivity and selectivity of the device with respect to the complex molecular\ud construct. The materials used for detection include nanoparticles and nanostructures fabricated\ud with different 2D and 3D lithographic methods. It is shown that sensitivity to a single molecule is\ud already accessible whether the system under study is a single cell or a multitude of cells in a\ud molecular mixture. Throughout the roadmPeer ReviewedAward-winningPostprint (author's final draft

Topics: Àrees temàtiques de la UPC::Física, Photonics, photonics, Fotònica
Publisher: IOP
Year: 2016
DOI identifier: 10.1088/2040-8978
OAI identifier: oai:upcommons.upc.edu:2117/90726
Journal:

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