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Assessing the impact of early detection biases on breast cancer survival of Catalan women

By Albert Roso-Llorach, Carles Forné, Francesc Macià, Jaume Galceran, Rafael Marcos-Gragera and Montserrat Rué

Abstract

Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.Peer Reviewe

Topics: Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica, Breast cancer, early detection, screening, lead time bias, length bias, survival, Classificació AMS::62 Statistics::62N Survival analysis and censored data, Classificació AMS::62 Statistics::62P Applications
Publisher: Institut d'Estadística de Catalunya
Year: 2014
OAI identifier: oai:upcommons.upc.edu:2117/88561
Journal:

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