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Understanding the Pathogenesis of Neuroinflammation using Magnetic Resonance Imaging

By Sonia Waiczies and Helmar Waiczies

Abstract

A non-invasive view of the brain with the aid of magnetic resonance imaging (MRI) is invaluable for studying pathological processes during autoimmune encephalomyelitis. Several MRI technologies are available that can be employed to study inflammation within the brain. These include labeling of inflammatory cells with paramagnetic contrast agents (such as USPIO/SPIO/VSOP iron-oxide or perfluoro carbon (PFC)-rich nanoparticles) and new tools that facilitate high resolution imaging particularly MR microscopy (µMRI, microscopic MRI; MR histology). In this review we will go into both MRI technologies, with a special focus on their applicability in studying brain inflammation in the experimental autoimmune encephalomyelitis (EAE). Regarding cell labeling we will focus on PFC nanoparticles and fluorine (19F) MRI since these have introduced a number of advantages over T2*-weighted MRI with paramagnetic iron-oxide nanoparticles. Another MRI technology that we will be discussing is high resolution µMRI with cryogenically-cooled RF coils. This technology will enable neuroscientists to achieve a comprehensive, detailed and non-invasive view of the brain within short acquisition times: an important practical consideration when conducting longitudinal studies on the kinetics and dynamics of immune cell infiltration into the brain

Topics: Neuritis -- Pathogenesis, Magnetic resonance imaging, Encephalomyelitis, Autoimmune, Experimental
Publisher: Malta Medical Journal
Year: 2011
OAI identifier: oai:www.um.edu.mt:123456789/1095
Provided by: OAR@UM

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Citations

  1. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. doi
  2. Ahrens ET Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. doi
  3. Beyond blood brain barrier breakdown - in vivo detection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI. doi
  4. Blackband S MR microscopy and high resolution small animal MRI: applications in neuroscience research. doi
  5. Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study. doi
  6. Caille JM Dose and scanning delay using USPIO for central nervous system macrophage imaging. doi
  7. Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study. doi
  8. Chiro G On the origin of paramagnetic inhomogeneity effects in blood. doi
  9. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. doi
  10. Cryogenically cooled probes − a leap doi
  11. Dendritic cells as vectors for therapy. doi
  12. developing lesion. Cell Immunol.
  13. Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis. doi
  14. Frank JA Cellular magnetic resonance imaging: current status and future prospects. Expert Rev Med Devices. doi
  15. GA Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain. doi
  16. Granum B () Adjuvant activity of particulate pollutants in different mouse models. doi
  17. Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. doi
  18. Hinshaw WS F-19 MagneticResonance Imaging.
  19. Image Formation by Induced Local Interactions - Examples Employing Nuclear MagneticResonance. doi
  20. Immunology: In the beginning. doi
  21. In vivo "hot spot" MR imaging of neural stem cells using fluorinated nanoparticles. doi
  22. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. doi
  23. Lees MB Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. doi
  24. Long DM Perfluoroctylbromide as a diagnostic contrast medium in gastroenterography. doi
  25. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. doi
  26. Magnetically labeled cells can be detected by MR imaging. doi
  27. McNeil SE Immunological properties of engineered nanomaterials. doi
  28. Morel PA In vivo imaging platform for tracking immunotherapeutic cells. doi
  29. MRI detection of single particles for cellular imaging. doi
  30. Nuclear magnetic resonance imaging of a single cell. doi
  31. Perfluorocarbon particle size influences magnetic resonance signal and immunological properties of dendritic cells. doi
  32. Physical approaches to biomaterial design. doi
  33. Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement. doi
  34. Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses. doi
  35. Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. doi
  36. Setzu A et al. Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain. doi
  37. Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. doi
  38. (1976). The signal-to-noise ratio of the nuclear magnetic resonance experiment. doi

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