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The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists

By Susan Napier, Grant Wishart, William Arbuckle, James Baker, David Barn, Matilda Bingham, Angus Brown, Alan Byford, Chris Claxton, Mark Craighead, Kirsteen Buchanan, Lee Fielding, Lindsay Gibson, Richard Goodwin, Susan Goutcher, Nicholas Irving, Cliona MacSweeney, Rachel Milne, Chris Mort, Jeremy Presland, Hazel Sloan, Fiona Thomson, Zara Turnbull and Trevor Young


The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V1A receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V1A antagonists

Publisher: Elsevier
Year: 2011
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Provided by: Enlighten
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