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A Distinct Signaling Pathway used by the IgG-Containing B Cell Antigen Receptor

By C. Wakabayashi, T. Adachi, J. Wienands and T. Tsubata

Abstract

The immunoglobulin G (IgG)-containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal- transducing component, Igα/Igβ. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22- mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens

Year: 2002
OAI identifier: oai:escidoc.org:escidoc:2349791
Provided by: MPG.PuRe
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