Skip to main content
Article thumbnail
Location of Repository

Role of interferons in LPS hypersensitivity

By M. Freudenberg, C. Kalis, Y. Chvatchko, T. Merlin, M. Gumenscheimer and C. Galanos

Abstract

The innate immune response to Gram-negative bacteria depends mainly on the ability of the host to respond to the LPS component. Consequently, the state of LPS sensitivity at the time of infection and the numbers of invading bacteria (i.e. the amounts of LPS) are primary factors determining the innate responses provoked by Gram-negative pathogens. LPS sensitivity increases following treatment of mice with live or killed micro-organisms. Two types of sensitization have been recognized, strong, IFN-γ-dependent and moderate IFN-γ-independent. IL-12 and IL-18 are intimately involved in the induction of IFN-γ by bacteria. We showed that Gram-negative bacteria induce IFN-γ in mice also by an IFN-β-dependent pathway that requires IL-18 and is independent of IL-12 signaling. This pathway is STAT4 dependent, the activation of which is directly linked to IFN-β. Further, IFN-β can be replaced by IFN-α. While different components of Gram-negative bacteria induce IL-12 and IL-18, LPS seems to be the only component in these bacteria capable of inducing IFN-β. Therefore, the IFN-β pathway of IFN-γ induction, unlike the IL-12 pathway, proceeds only in LPS responder mice. The IFN-α/β-dependent pathway is expected to play a role whenever IFN-α or IFN-β, and IL-18 are produced concomitantly during infection

Year: 2003
OAI identifier: oai:escidoc.org:escidoc:2349774
Provided by: MPG.PuRe
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://hdl.handle.net/11858/00... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.