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Unexpected Beneficial Effect of ortho-Substituents on the (S)-Proline-Catalyzed Asymmetric Aldol Reaction of Acetone with Aromatic Aldehydes

By A. Martínez, M. van Gemmeren and B. List


An intriguing effect of electronegative 2,6-substituents on the stereochemical outcome of (S)-proline-catalyzed aldol reactions between benzaldehyde derivatives and acetone is reported. Remarkably high enantioselectivities can be achieved with such substrates

Year: 2014
DOI identifier: 10.1055/s-0033-1340920
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Provided by: MPG.PuRe
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