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Role of transcription factors in commitment and differentiation of early B lymphoid cells

By S. Roessler and R. Grosschedl

Abstract

B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation

Year: 2006
OAI identifier: oai:escidoc.org:escidoc:2349480
Provided by: MPG.PuRe
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