Skip to main content
Article thumbnail
Location of Repository

Warwick hip trauma study : a randomised clinical trial comparing interventions to improve outcomes in internally fixed intracapsular fractures of the proximal femur : protocol for The WHiT Study

By Xavier L. Griffin, Nicholas R. Parsons, Juul Achten and Matthew L. Costa

Abstract

Background\ud Controversy exists regarding the optimal treatment for patients with displaced intracapsular fractures of the proximal femur. The recognised treatment alternatives are arthroplasty and internal fixation. The principal criticism of internal fixation is the high rate of non-union; up to 30% of patients will have a failure of the fixation leading to revision surgery. We believe that improved fracture healing may lead to a decreased rate of failure of fixation. We therefore propose to investigate strategies to both accelerate fracture healing and improve fixation that may significantly improve outcomes after internal fixation of intracapsular femoral fractures. We aim to test the clinical effectiveness of the osteoinductive agent platelet rich plasma and conduct a pilot study of a novel fixed-angle fixation system.\ud \ud Design\ud We have planned a three arm, single centre, standard-of-care controlled, double blinded, pragmatic, randomised clinical trial. The trial will include a standard two-way comparison between platelet-rich plasma and standard-of-care fixation versus standard-of-care fixation alone. In addition there will be a subsidiary pilot arm testing a fixed-angle screw and plate fixation system.\u

Topics: RD
Publisher: BioMed Central Ltd.
Year: 2010
OAI identifier: oai:wrap.warwick.ac.uk:3366

Suggested articles

Citations

  1. (2007). A Phase 2, Multicenter, Single-Blind, Randomized, Stratified, Standard-of-Care Controlled, Feasibility and Safety Study of rhBMP-2/CPM as an Adjuvant Therapy for Fractures of the Proximal Femur.
  2. (2004). An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int doi
  3. (2002). GA: Hemiarthroplasty versus internal fixation for displaced intracapsular hip fractures in the elderly. A randomised trial of 455 patients. The Journal of bone and joint surgery doi
  4. (1993). Garden grading of intracapsular fractures: meaningful or misleading? Injury doi
  5. (2007). Gurusamy K: Incidence of fracture-healing Complications after Femoral Neck Fractures. Clinical Orthopaedics and Related Research doi
  6. (2006). Gurusamy K: Internal fixation versus arthroplasty for intracapsular proximal femoral fractures in adults. Cochrane Database Syst Rev doi
  7. (1996). Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA doi
  8. (1961). Low-Angle fixation in fractures of the femoral neck. The Journal of bone and joint surgery
  9. (2009). ML: The clinical use of platelet-rich plasma in the promotion of bone healing: a systematic review. Injury doi
  10. (2008). Preliminary results of a new dynamic locking plate and screw system for intracapsular hip fractures. Injury Extra doi
  11. (1976). Treatment of fractures of the femoral neck by replacement with the Thompson prosthesis. The Journal of bone and joint surgery
  12. (1994). Wennberg JE: Outcomes after displaced fractures of the femoral neck. A meta-analysis of one hundred and six published reports. The Journal of bone and joint surgery doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.