Skip to main content
Article thumbnail
Location of Repository

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans

By Christian von Loeffelholz, Matthias Möhlig, M. Ayman Arafat, Frank Isken, Joachim Spranger, Knut Mai, Harpal S. Randeva, Andreas F. H. Pfeiffer and Martin O. Weickert


Objective: To study the association of vaspin with glucose metabolism. \ud \ud Design: Cross-sectional and intervention study. \ud \ud Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic–hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally studied in a crossover study using 300 min EHC with lipid versus saline infusion (n=10). \ud \ud Results: Neither glucose tolerance status nor insulin sensitivity, both as measured using EHCs and using homeostasis model assessment for insulin resistance (HOMA-IR), was significantly associated with serum vaspin in the cross-sectional study. Furthermore, there was no effect of short-term lipid-induced insulin resistance due to a 300 min intravenous lipid challenge on circulating vaspin. However, circulating vaspin levels were significantly elevated in women using oral contraceptives (OC), both compared to women without OC intake (1.17±0.26 vs 0.52±0.09 ng/ml, P=0.02) and males (1.17±0.26 vs 0.29±0.04 ng/ml, P=0.01). After exclusion of OC using females and stratification according to body mass index (BMI), a significant sexual dimorphism in subjects with a BMI <25 kg/m2 was observed (males 0.21±0.04 ng/ml versus females 0.70±0.16 ng/ml, P=0.009). \ud \ud Conclusion: Our results support the existence of a sexual dimorphism regarding circulating vaspin. The lack of an association of serum vaspin with HOMA-IR and M value indicates, however, no major role for vaspin concerning insulin sensitivity in nondiabetic humans. \ud \u

Topics: QP
Publisher: BioScientifica Ltd.
Year: 2010
OAI identifier:

Suggested articles


  1. (2009). A & Gurlek A: Serum vaspin levels in type 2 diabetic women in relation to microvascular complications. doi
  2. (2008). Adipokines and insulin resistance. doi
  3. (2008). AF: Effects of euglycemic hyperinsulinemia and lipid infusion on circulating cholecystokinin. doi
  4. (2008). et al.: KCNJ11 E23K affects diabetes risk and is associated with the disposition index: results of two independent German cohorts. Diabetes Care doi
  5. (1979). Glucose clamp technique: a method for quantifying insulin secretion and resistance.
  6. (2009). Luger A & Kautzky-Willer A: Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss. Obesity Surgery doi
  7. (1994). Mechanisms of fatty acid-induced inhibition of glucose uptake. doi
  8. (2007). Pfeiffer AF & Möhlig M: A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. doi
  9. (2008). Randeva HS: Metformin decreases the adipokine vaspin in overweight women 16 with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. Diabetes doi
  10. (2008). Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. doi
  11. (2008). Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes doi
  12. (2008). Takahashi T: A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. doi
  13. (2006). Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. doi
  14. (2009). Vaspin serum concentrations in patients with carotid stenosis. Atherosclerosis doi
  15. (2008). Vaspin: a novel serpin with insulin-sensitizing effects. doi
  16. (2005). YS: Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.