Skip to main content
Article thumbnail
Location of Repository

Photoactivated chemotherapy (PACT) : the potential of excited-state d-block metals in medicine

By Nicola J. Farrer, Luca Salassa and P. J. Sadler

Abstract

The fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over drug activation and has remarkable potential for the treatment of cancer. Following photoexcitation, a number of different decay pathways (both photophysical and photochemical) are available to a metal complex. These pathways can result in radiative energy release, loss of ligands or transfer of energy to another species, such as triplet oxygen. We discuss the features which need to be considered when developing a metal-based anticancer drug, and the common mechanisms by which the current complexes are believed to operate. We then provide a comprehensive overview of PACT developments for complexes of the different d-block metals for the treatment of cancer, detailing the more established areas concerning Ti, V, Cr, Mn, Re, Fe, Ru, Os, Co, Rh, Pt, and Cu and also highlighting areas where there is potential for greater exploration. Nanoparticles (Ag, Au) and quantum dots (Cd) are also discussed for their photothermal destructive potential. We also discuss the potential held in particular by mixed-metal systems and Ru complexes

Topics: RC0254, RM
Publisher: Royal Society of Chemistry
Year: 2009
OAI identifier: oai:wrap.warwick.ac.uk:3428

Suggested articles

Citations

  1. (2008). 235–237; d doi
  2. Anti-Cancer Agents in Med. doi
  3. (2005). Drug Discovery Dev.,
  4. (2007). For metals a) Cr, Cu, Ru, Rh see Vol I
  5. (2003). Gastrointest Endosc., doi
  6. in Metal Complexes for Photodynamic Therapy, Comprehensive Coordination Chemistry II, doi
  7. (2006). Mesmaeker, Coord. Chem Rev.,
  8. (2009). Photodynamic Ther., doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.