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A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure

By Sarah E. Medland, Tetyana Zayats, Beate Glaser, Dale R. Nyholt, Scott D. Gordon, Margaret J. Wright, Grant W. Montgomery, Megan J. Campbell, Anjali K. Henders, Nicholas J. Timpson, Leena Peltonen, Dieter Wolke, Susan M. Ring, Panos Deloukas, Nicholas G. Martin, George Davey Smith and David M. Evans

Abstract

The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 2D:4D, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 108) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 106). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 2D:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure

Topics: QP, RG
Publisher: Elsevier
Year: 2010
OAI identifier: oai:wrap.warwick.ac.uk:3863

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Citations

  1. (2003). 2nd to 4th digit ratio and a universal mean for prenatal testosterone in homosexual men. Med Hypotheses 61:303-306 15. Rahman Q and Wilson GD doi
  2. (2008). 6669 Caucasian rs6060369 20 BFZB C positive 2 x 10 -16 positive 0.52 rs17690232 4 PDGFRA C positive 4 x 10 -7 positive 0.64
  3. (2008). ADAMTSL3, SH3GL3 T positive 9 x 10 -7 negative 0.87 rs2814828 9 SPIN1, CCRK T positive 9 x 10 -7 positive 0.65 rs7249094 19 ADAMTS10, MYO1F, PRAM1,
  4. (2009). gene associated with height identified by linkage and genomewide association analysis.
  5. (2008). Genetic and environmental influences on 2D:4D finger length ratios: a study of monozygotic and dizygotic male and female twins. Arch Sex Behav 37:112-118 19. Medland SE, Loehlin JC doi
  6. (2009). Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet 41:729-733 28. Abecasis doi
  7. (2009). Lin28 promotes transformation and is associated with advanced human malignancies. doi
  8. (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. doi
  9. (2008). negative 0.42 rs1042725 12 HMGA2 C positive 3 x 10 -18 negative 0.94 rs6060373 20 GDF G negative 2 x 10 -17 positive 0.53 rs16896068 4 LCORL A negative 2 x 10 -13 positive 0.58
  10. (2009). Ong et al. Genetic variation in LIN28B is associated with the timing of puberty. doi
  11. (2009). positive 0.47 Estrada et al. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. doi
  12. (2008). positive 6 x 10 -6 positive 0.90 rs4345115 3 GOLIM4, SERPINI1 T positive 7 x 10 -6 positive 0.72
  13. (1952). Relative finger lengths as a sex-influenced trait in
  14. (2009). Scientometric analysis and bibliography of digit ratio (2D:4D) research, 1998-2008. Psychol Rep 104:922-956 9. Manning doi
  15. (2009). Sulem et al. Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. doi
  16. (2003). The 2nd to 4th digit ratio and variation in the androgen receptor gene. Evolution and Human Behavior 24:399-405 23. Golding doi
  17. (2008). x 10 -20 positive 0.94 rs4896582 6 GPR126 A negative 2 x 10 -18 negative 0.33 rs10946808 6 HIST1H1D G negative 4 x 10 -17 negative 0.57 rs6060369 20 GDF5, UQCC C positive 1 x 10 -16 positive 0.52 rs1492820 4
  18. (2009). ZBTB38, ACPL2 A positive 8 x 10 -8 positive 0.54 rs10961780 9 FREM1 G negative 2 x 10 -6 positive 0.37 rs2079795 17 C17orf82, TBX2, TBX4 T positive 3 x 10 -6 positive 0.23

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