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Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism

By K. S. OZAKI, G. M. MARQUES, E. NOGUEIRA, R. Q. FEITOZA, M. A. CENEDEZE, M. F. FRANCO, M. MAZZALI, M. P. SOARES, A. PACHECO-SILVA and N. O. S. CAMARA

Abstract

Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. The HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (< 27 repeats) and long repeats (L) (>= 27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN

Topics: graft survival, heme oxygenase-1, polymorphism, renal graft function, renal transplantation, NF-KAPPA-B, ENDOTHELIAL GROWTH-FACTOR, MICROSATELLITE POLYMORPHISM, GENE PROMOTER, ISCHEMIA/REPERFUSION INJURY, PROTECTIVE GENES, ALLOGRAFT REJECTION, REPERFUSION INJURY, GRAFT-SURVIVAL, EXPRESSION, Surgery, Transplantation
Publisher: WILEY-BLACKWELL
Year: 2013
OAI identifier: oai:agregador.ibict.br.RI_UNICAMP:oai:unicamp.sibi.usp.br:SBURI/958
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