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Epidemiological and clinical patterns of 92 patients co-infected with HIV and Mycobacterium leprae from Rio de Janeiro State, Brazil

By Vinícius Martins de Menezes, Jose Augusto da Costa Nery, Anna Maria Sales, Alice Miranda, Maria Clara Gutierrez Galhardo, Francisco Inácio Pinkusfeld Monteiro Bastos, Euzenir Nunes Sarno and Mariana de Andrea Vilas-Boas Hacker


Background: Many articles have shown that HIV infection can modify the clinical course of leprosy, but very scant epidemiological and clinical data about this co-infection are available in the peer-reviewed literature. Methods: We herein describe the geographical distribution and demographic characteristics of 92 HIV/ Mycobacterium leprae co-infected patients assisted in a Brazilian Leprosy referral center. A multivariate analysis was performed in order to establish clinical factors associated with type 1 reaction. Results: Co-infected patient admissions have steadily increased over the last years at this referral center. Most patientswere men, with a mean age of 32.3 years and presenting with the paucibacillary form of leprosy. The use of antiretroviral therapy (ART) was the only factor associated with type 1 reaction. Most patients were living in the metropolitan area and the north sub area of Rio de Janeiro City. Conclusion: Co-infected patients receiving ART have a greater chance to develop type 1 reaction. Patients living with both HIV and leprosy are likely to live in regions characterized by a high density impoverished populatio

Topics: HIV, Leprosy and HIV Coinfection, Social Geography of Leprosy, Type 1 Reaction, HIV, Hanseníase, Coinfecção, Antirretrovirais /uso terapêutico, Análise Multivariada, Brasil/ epidemiologia
Publisher: Oxford University Press
Year: 2014
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