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Flavonoids and other bioactive phenolics iso lated from Cenostigma macrophyllum (leguminosae)

By Clayton Queiroz Alves, Jorge Mauricio David, Juceni Pereira de Lima David, Cristiane Flora Villarreal, Milena Botelho Pereira Soares, Luciano Paganucci de Queiroz and Rosane M. Aguiar


This work describes the phytochemical study of stem bark and leaves of Cenostigma macrophyllum Tul. (Leguminosae). Through usual chromatographic techniques were isolated bergenin as the primary compound of the stem bark of and from the leaves gallic acid, methyl gallate, ellagic acid, quercetin, quercetin-3-O-β-D-glucopyranoside, quercetin-3-O-(6’’-O-galloyl)-β-D-glucopyranoside (tellimoside), quercetin-3-O-(6’’-O-E-p-coumaroyl)-β-D-glucopyranoside (helichrysroside), agathisflavone and vitexin were obtained. The isolates were identified by spectroscopic data analysis, and bergenin showed dose-related antinociception when assessed in acetic acid-induced writhing in mice

Topics: Cenostigma macrophyllum, Cenostigma gardnerianum, Antinociceptive activity
Publisher: Sociedade Brasileira de Química
Year: 2012
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