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Association phenothiazine and laser on growth of C. tropicalis fluconazole-resistant

By Rafael Araújo Gomes Júnior, Susana Carla Pires Sampaio Oliveira, Juliana Santos de Carvalho Monteiro, Gustavo Miranda Pires Santos, Fernando José Pires Sampaio, Maria de Fatima Malvar Gesteira, Fátima A. A Zanin, Aldo Brugnera Junior, Antonio Luiz Barbosa Pinheiro and Marcos André Vannier dos Santos

Abstract

Candidiasis is caused by Candida species found on the skin, gastrointestinal tract and mucous cavities of the humans and may be acute, chronic, localized or systemic. Alhough C. albicans is the species most often identified as responsible for this type of infection C. Tropicalis has been considered an emerging cause. The effect of the association of phenothiazine - PTZ and laser on fluconazole-resistant C.tropicalis growth was tested. 2.5 x 106 CFU/mL 100mg/mL of phenothiazine with the pre-irradiation time of 10 min were irradiated with laser light (660 nm; 4.8 and 12 J/cm2 (L1 and L2 respectively) 40 mW) followed by incubation in RPMI for 24h. The following conditions were tested: control (control), laser (L1 and L2), phenothiazine (F1 and F2), and PACT (F1L1 and F2L2). Statistically significant diferences were seen between groups (L-F +) and (F + L +) for both conditions of the laser, with a growth inhibition of the yeast around 67 and 51%, respectively, however, when using only the laser there was an increase of 18% in the survival of these cells. PACT´s efficacy on fluconazole-resistant C. tropicalis depended on both the time of pre-irradiation and concentration of the PTZ

Topics: Candidiase, Candida albicans, Fluoconazol, Laser
Publisher: SPIE
Year: 2014
OAI identifier: oai:agregador.ibict.br.RI_FIOCRUZ:oai:localhost:icict/7598
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