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Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil

By Ana Marlucia de Oliveira, Maurício Lima Barreto, Matildes da Silva Prado, Mitermayer Galvão dos Reis, Isabel Martin Parraga and Ronald Edward Blanton


Brazilian schoolchildren with mild- to moderate-intensity schistosome infections (<400 Schistosoma mansoni eggs/g stool) were randomly allocated to a treatment (oxamniquine) or placebo group in a double-blind fashion. Anthropometric measurements were made at baseline, 6 mo, and 1 y for 353 students. At baseline, the groups were not significantly different with respect to nutritional status or selected socioeconomic and biological characteristics, including anthropometric measures. One year later, significant differences were noted only in the nutritional status of boys treated for schistosome infection. Treated boys had greater measurements for weight, triceps skinfold thickness, midarm circumference, arm muscle area, and body mass index than untreated boys. They also showed significant increases over the year in weight, height, midarm circumference, and body mass index. The rates of improvement in weight and height were more accelerated in the first 6 mo after therapy than the last. These results indicate that, at least in boys, chronic S. mansoni infection at any intensity is detrimental to short-term growth and development

Topics: Schistosoma mansoni, Growth, Sex, Oxamniquine, Morbidity, Therapy, Anthropometry, Parasitic infection, Schoolchildren, Estado Nutricional, Oxamniquine/uso terapêutico, Esquistossomose mansoni/quimioterapia, Esquistossomicidas/uso terapêutico, Adolescente, Antropometria, Índice de Massa Corporal, Peso Corporal, Brasil, Criança, Método Duplo-Cego, Feminino, Humanos, Masculino, Placebos, Esquistossomose mansoni/fisiopatologia, Pregas Cutâneas
Publisher: American Society for Clinical Nutrition
Year: 1998
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