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Hepatitis C virus genotypes in a northeastern area of Brazil

By Luciano Kalabric Silva, Raymundo Paran??, S??rgio P Souza, Francoise Berby, Alan Kay, Christian Trep??, Nelma Santana, Helma Cotrim, Luiz G Lyra and Mitermayer Galv??o dos Reis


We used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from a Gastro-Hepatology Unit in the city of Salvador (Bahia State) in northeastern Brazil. Viral RNA was detected in 83 (65.4%) of 127 anti-HCV seropositive serum samples. Positivity was significantly associated with alterations in levels of aspartate aminotransferase and alanine aminotransferase (P < 0.05). Genotyping of HCV was performed by RT-PCR using genotype-specific primers from the core region: 24.1% were infected with subtype 1a, 38.6% with 1b, 3.6% with 2, 21.7% with 3a, and 12.0% with a mixed genotype. There was no difference in genotype distribution when compared with results from other Brazilian locations. Surprisingly, the high frequency of genotype 3 in Brazilian samples continues to be different from that reported around the world and warrants further investigatio

Topics: Hepacivirus/gen??tica, Hepatite C/virologia, Adolescente, Adulto, Idoso, Alanina Transaminase/sangue, Aspartato Aminotransferases/sangue, Southern Blotting, Brasil/epidemiologia, Primers do DNA/qu??mica, DNA Viral/qu??mica, Feminino, Gen??tipo, Hepacivirus/qu??mica, Hepacivirus/classifica????o, Hepatite C/sangue, Hepatite C/epidemiologia, Humanos, T??cnicas Imunoenzim??ticas, Masculino, Meia-Idade, RNA Viral/qu??mica, RNA Viral/qu??mica, Rea????o em Cadeia da Polimerase Via Transcriptase, Estudos Soroepidemiol??gicos
Year: 2000
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