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Seroprevalence and factors associated with herpes simplex virus type 2 among HIV-negative high-risk men who have sex with men from Rio de Janeiro, Brazil: a cross-sectional study

By Junia Rodrigues, Beatriz Gilda Jegerhorn Grinsztejn, Francisco In??cio Pinkusfeld Monteiro Bastos, Luciane Velasque, Paula Mendes Luz, Claudia Teresa Vieira de Souza, Ingebourg Georg, Jose Henrique da Silva Pilotto and Valdil??a Gon??alves Veloso dos Santos

Abstract

Background: Herpes simplex virus type 2 (HSV-2) is the leading cause of genital ulcer disease in developing countries, including Brazil, and is especially prevalent among men who have sex with men (MSM). HSV-2 infection represents a risk factor for the acquisition and transmission of other sexually transmitted diseases. The goal of the present cross-sectional study was to estimate HSV- 2 seroprevalence and to determine the factors associated with HSV-2 seropositivity in HIVnegative high-risk MSM from Rio de Janeiro, Brazil. Methods: Stored sera were tested to estimate HSV-2 seroprevalence, while socio-demographic and sexual behavior data were used to measure associations between risk factors and HSV-2 seropositivity. Using the Poisson regression model with robust variance, prevalence ratios (PR) were used to estimate de degree of association between risk factors and HSV-2 seropositivity in bivariate and multivariate analyses. Results: Seroprevalence of HSV-2 was of 45.7% (184 out of 403). Factors independently associated with HSV-2 seroprevalence in the multivariate model were: older age (??? 26 years, PR: 1.41 95% Confidence Interval: 1.11???1.78), non-white race (PR: 1.32 95%CI: 1.06???1.64), positive serology for syphilis (PR: 1.65 95%CI: 1.33???2.05), positive serology for hepatitis B (PR: 1.25 95%CI: 0.99???1.57), stable male partner in the past 6 months (PR: 1.42 95%CI: 1.12???1.79), and unprotected anal sex with a stable female partner (PR: 1.46 95%CI: 1.05???2.04) in the 6 months preceding the crosssectional assessment. Conclusion: The present study made evident a high prevalence of HSV-2 infection in a sample of HIV-negative high-risk MSM from Rio de Janeiro. This finding indicates the need and urgency for implementing integrated programs for the prevention of HSV-2 and other sexually transmitted diseases, and, in particular, programs targeting high-risk MSM

Year: 2009
OAI identifier: oai:agregador.ibict.br.RI_FIOCRUZ:oai:localhost:icict/1255
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