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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

By Daisy M.F. Salvadori, Lúcia R. Ribeiro, Marília D.M. Oliveira, Carlos A.B. Pereira and Willy Beçak

Abstract

Texto completo. Acesso restrito. p. 237–244The influence of ß-carotene on the clastogenicity of the indirect-acting mutagen cyclophosphamide (CPA) was investigated in mice, in vivo, for the induction of chromosome aberrations in bone marrow cells (BM). ß-Carotene (0.5, 1.0, 2.0, 5.0, 10, 25, 50, 100 and 200 mg/kg) was administered by gavage for 5 consecutive days. 4 h after the last treatment with ß-carotene, the mice were injected intraperitoneally with CPA, and the BM cells were fixed after 16, 24 and 32 h for the evaluation of the frequency of chromosome aberrations. The results showed that ß-carotene was effective in reducing chromosomal damage induced by CPA with the increase of its concentration up to a level after which this effect was not observed. This anticlastogenicity was better detected when the cells were fixed at 32 h, although a tendency in reducing the CPA clastogenicity was already observed at 16 and 24 h. Our results suggest that ß-carotene provides significant protection against the genotoxicity of CPA, although no dose-effect relationship on the frequencies of cells with chromosomal aberrations was observed

Topics: Antimutagenesis, ß-Carotene, Chromosome aberration, Cyclophosphamide
Publisher: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Year: 2013
OAI identifier: oai:agregador.ibict.br.RI_UFBA:oai:192.168.11:11:ri/13523
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