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By Cristiane C. Frota, Max V.C. Freitas, Norma T. Foss, Luana N.C. Lima, Laura C. Rodrigues, Maurício Lima Barreto and Ligia R.S. Kerr


Acesso restrito:Texto completo. p.490-495The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceará, Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from noncases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas

Topics: Leprosy, Mycobacterium leprae, Seroprevalence, Immunologic marker, Phenolic glycolipid-I, Brazil
Year: 2012
OAI identifier: oai:agregador.ibict.br.RI_UFBA:oai:192.168.11:11:ri/5768
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