Skip to main content
Article thumbnail
Location of Repository

Studies on the cardiovascular actions of hydralazine.

By Virgílio Durão and Assunção Elvas

Abstract

In conscious normotensive rabbits, the intravenous administration of hydralazine (0.3 mg/Kg) induced a significant decrease of mean arterial blood pressure (MBP) (p<0.001) and a significant increase of heart rate (HR) (p< 0.01). Pretreatrnent ot the animals with two prostaglandins (PGS) synthesis inhibitors, indomethacin (1  mg/Kg) and acetyisalicylic acid (10 mg/Kg) abolished the hypotensive effect (p> 0.05) and did not modify the tachycardia. In the same model, the continuous infusion of a PGS precursor, arachidonic acid (7.5-10 μg/Kg/min), modified the blood pressure lowering effect of hydralazine which began sooner and was considerably prolonged. In spontaneously beating guinea-pig isolated atria, hydralazine (X10-5M) had no direct chronotropic effect and did not rnoclify the responses to noradrenaline (2 to 8X10—7M) and isoprenaline (1 to 4X10-8M), but markedly enhanced the tachycardia provoked by tyramine (1.5 and 3.0x10-5M). These results suggest that the hypotensive effect of hydralazine in normotensive conscious rabbits are related to the endogenous PGS system and that hydralazine has a stimulating effect on the heart probably mediated by a modification of the adrenergic neurotransmission to the heart

Publisher: Ordem dos Médicos
Year: 1979
OAI identifier: oai:ojs.www.actamedicaportuguesa.com:article/1270
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.rcaap.pt/detail.jsp... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.